Senior Scientist- DMPK

2 weeks ago

Vizag, Andhra Pradesh, India Aurigene Oncology Limited Full time

Desired Profile: M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry) with 12-15 years or Ph.D. with 5 years' experience

Job Description, Key Skills and Competencies:

  • Expert in designing and executing DMPK studies to support antibody-drug conjugate (ADC) and monoclonal antibody (mAb) programs, from discovery through IND-enabling stages.
  • Extensive experience in quantification of biologics including antibodies, therapeutic proteins, ADCs, and peptides using LC-MS/MS, MSD, and ELISA platforms.
  • Proficient in advanced bioinformatics tools such as BioPharma Finder, MaxQuant, Spectronaut, and other relevant analytical software.
  • Skilled in applying innovative techniques for function-based identification and selection of ADC and mAb lead candidates, with a strong focus on DMPK profiling to ensure safe and effective therapeutic development.
  • Experienced in interpreting complex DMPK data and providing actionable insights to cross-functional project teams.
  • Actively represent DMPK functions in internal and external meetings, fostering collaboration and strategic alignment.
  • Collaborate closely with cross-functional departments to address ADC-related challenges and deliver integrated solutions from target validation to IND submission.
  • Accountable for authoring and reviewing SOPs, study protocols, reports, and regulatory documentation to support both GLP and non-GLP studies.
  • Strong foundational knowledge of DMPK principles, including PK/PD, toxicology, and translational sciences. Demonstrated capabilities in communication, innovation, and team leadership.

Competencies:

  • Antibody, ADC characterisation
  • Communication Skills
  • Excel software Skills
  • Interpersonal Skills

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