Biologist - Cellular & Molecular Biology

2 weeks ago


Ahmedabad, Gujarat, India O2h Full time
Reporting to senior team leader, work with a group of in vitro assay biologists, learning and coaching group members to improve skills and productivity

  • Independently design, conduct, optimize and proactively troubleshoot assays
  • Develop, optimize and validate biochemical and cellbased assay platforms for the hit identification, lead optimization and functional characterization of small molecules
  • Work on the bench implementing stateoftheart technologies for the different assay platforms
  • Ensure robust and highquality assays with efficient use of automation and instrumentation
  • Data processing, interpretation and presentation to cross functional team members and
  • Proposing, planning, quoting, tracking reagent needs, usage and executing time lines for each study
  • Work closely with other biology groups involved in screening, cell biology, protein biology and ADME, offering integrated drug discovery support alongside chemistry for multiple clientbased projects

Job requirements:

  • Experience in assay development and ability to handle 96 and 384well formats
  • Basic understanding of molecular biology, cell biology and biochemistry techniques
  • Working knowledge of sitedirected mutagenesis, transcriptional studies, luciferase reporter assays and qRTPCR
  • Cell culture experience and in handling different immortalized cell lines, primary cell lines and 3D cultures
  • Ability to perform transient transfections and generate stable cell lines
  • Good working knowledge of immunoprecipitation and Western blotting for protein analysis and quantification
  • Experience in fluorescence microscopy and highcontent imagining is an added advantage
  • Experience in targeted protein degradation, target engagement assays (e.g. nanoBRET, CETSA) is an added advantage
  • Experience in CRISPR-CAS9 knockout and siRNa/shRNA knockdown studies is an added advantage
  • Excellent data analysis and interpretation skills
  • Ability to participate in project team meetings and contribute to the project(s) intellectually
  • Ability to overcome technical challenges and exercise sound judgment under pressure
  • High selfmotivation to initiate projects and work independently under aggressive deadlines
  • An excellent personal rapport and an ability to engender trust and respect
  • An ability to work well as part of a small focussed team and build relationships
  • An exceptional communication skill and an ease in interaction with all stakeholders
  • An infectious enthusiasm for life, work and making a difference to the world in which we live
  • A bright, friendly, flexible personality with agility to switch between different skill sets
  • An exceptional organizational skill that thrives working in a fastpaced and vibrant team environment
  • Positivity, focus and a winning mentality allied with kindness
  • Curiosity, energy, creativity, and bravery with a strong desire to help to build the o2h culture


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