Drug Delivery Specialist

7 days ago

Bengaluru, India Technoculture Research Pvt. Ltd. Full time

Job Title: Drug Delivery Specialist


Location: C-CAMP, Bangalore


Job Type: Full-Time


Joining Type: Immediate


About Us:

Technoculture Research Pvt Ltd is at the forefront of healthcare innovation, specializing in advanced pharmacogenomics, DNA analysis for early disease detection, and precise infectious disease diagnosis. Our expertise spans Molecular Biology, Electrochemical Sensing, Biomarkers, and SNP Testing, enabling us to deliver accurate, personalized medical solutions. We are dedicated to improving patient outcomes and advancing medical diagnostics through cutting-edge technology and innovative solutions.


About Our Sister Company:

EXRNA Therapeutics Limited is a pioneering drug development company focused on discovering potential cures for autoimmune diseases. Leveraging advanced Extracellular RNA (exRNA) based therapies, we aim to accelerate the development of innovative treatments, benefiting patients and healthcare providers alike. Join us as we revolutionize autoimmune disease therapy with cutting-edge scientific advancements.


Job Summary:

We are seeking a dedicated Drug Delivery Specialist with a strong background in oligonucleotide synthesis and characterization. The ideal candidate will hold a PhD in Chemistry with post-doctoral research experience and industrial expertise in oligonucleotide and peptide synthesis. This role involves the development and characterization of novel drug delivery vehicles and requires a deep understanding of chemical modifications in oligonucleotide drug design.



Key Responsibilities:

  • Synthesize and characterize oligonucleotides (DNA, RNA) with various modifications, including Locked Nucleic Acid (LNA), 2'F, 2'OMe, 2'MOE, and morpholino oligonucleotides (PMO).
  •    Develop and optimize drug delivery vehicles for oligonucleotide therapeutics.
  •    Conduct assays to analyze the efficacy and stability of novel drug delivery vehicles.
  •   Perform conjugation of oligonucleotides with peptides (CPP, fluorescent tags, etc.) and small molecules using different chemical reactions (amide, click, enzyme, etc.).
  •    Synthesize antisense oligonucleotides (ASOs) with Phosphodiester and Phosphorothioate (PS) linkages.
  •   Develop methods for purification and characterization of chemically modified and conjugated oligonucleotides using techniques such as HPLC, IEX, SEC, Precipitation, and Gel.
  •   Utilize various analytical techniques (LCMS, MALDI, etc.) for detailed characterization of oligonucleotides.
  •  Collaborate with cross-functional teams to drive research projects and contribute to the development of new drug delivery systems.
  •   Maintain accurate and detailed records of experiments and results.



Qualifications:

  •       PhD in Chemistry with a focus on oligonucleotide and peptide synthesis.
  •       Strong background in oligonucleotide synthesis and characterization.
  •       In-depth understanding of various modifications involved in oligonucleotide drug design.
  •       Experience in developing and optimizing drug delivery vehicles.
  •       Proficiency in conducting assays for the analysis of drug delivery systems.
  •       Post-doctoral research experience and industrial experience in the field.
  •       Demonstrated history of working with synthesis and modifications of oligonucleotides, including conjugation with peptides and small molecules.
  •       Experience in method development for purification and characterization of oligonucleotides.
  •       Familiarity with analytical techniques such as LCMS and MALDI.
  •       Strong problem-solving skills and attention to detail.
  •       Excellent communication and teamwork skills.



Personal Attributes:

  •       Innovative Thinker: Ability to develop novel solutions for complex problems in drug delivery.
  •       Detail-Oriented: Ensuring accuracy and precision in all aspects of research and analysis.
  •       Adaptable: Flexibility to adapt to new challenges and changes in project directions.
  •       Collaborative: Strong interpersonal skills with a proven ability to work effectively in a team environment.
  •     Driven and Self-Motivated: Proactive in seeking new opportunities for research and development, with a strong sense of initiative.
  •     Effective Communicator: Excellent verbal and written communication skills, capable of conveying complex scientific information clearly and concisely.
  •       Organized: Strong organizational skills with the ability to manage multiple projects simultaneously and meet deadlines.



About C-CAMP:

C-CAMP (Centre for Cellular and Molecular Platforms) is a premier innovation hub in Bangalore, India, dedicated to providing cutting-edge research and development support in the field of biotechnology. We are committed to fostering innovation and excellence and making significant contributions to the scientific community.


About Position:

Join us at Technoculture Research Pvt Ltd and EXRNA Therapeutics Limited, where your expertise will help shape the future of healthcare. Apply now and be a part of our mission to enhance healthcare with cutting-edge technology and innovative solutions.


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