Pharmacologist

Position - Associate Team Lead (Sr.Executive/ Asst Manager level)

Location - R&D, Shamirpet, Hyderabad

Purpose: Responsible for designing and executing small molecule screening assays working closely with stake holders (medicinal chemists, ADME, in vivo biologists, and project management teams), adapting state-of the-art automated instrumentation and digitalized data acquisition systems.

Key Responsibilities

Operational

1. Develop in vitro biochemical or cell-based assays: its optimization and validation, using 96 and 384 assay formats and readouts, to enable screening of NCE. Should be familiar with performing in vitro assays using various readouts-Absorbance, Fluorescence, FP, TR-FRET, HTRF, chemiluminescence etc. Experience in handling JESS, Novocyte/flow cytometers, Incucyte, Envision, Luminex and other plate readers.
2. Familiar with WB, ELISA, FACS, basic molecular biology.
3. Perform MoA assays for Oncology, IO, and inflammation using cell lines and/or primary cells using in vivo disease samples or primary human PBMC derived immune cell subsets in co-culture assays, for PD marker identification etc.
4. Basic molecular biology (cloning and cell line generation, protein estimation by WB and QC) is preferable but not a must.
5. Experience in performing screening assays for PROTACS: WB degradation assays, Nano-BRET, ternary complex formation.
6. Perform routine literature surveys and stay up to date on scientific advances related to the projects and identify areas of improvisation.
7. Work closely with project stakeholders from the scientific and support staff to enable smooth project progress and milestone achievements.
8. Prepare technical and scientific presentations for weekly and biweekly meetings on project updates and way forward. Manage client expectations with on-time delivery with quality data and communication skills.
9. Meticulous data documentation using eLNBs, followed by data compilation and communication to clients in a timely manner with critical interpretation and way-forward recommendations.
10. Meticulous and strict adherence to SOPs, data acquisition, analysis and documentation, adhering to the principles of GLP Laboratory. Follow principles of GLP for study execution and implement good lab practices for instrument maintenance, follow up activities on instrument AMC, etc.
11. Plan reagent requirement and ordering as per project requirements in a timely manner.
12. Preparation of quotes for project related activity, operational activity in the labs and procurement etc.
13. Support the TL in drafting of project proposals, preparation of quotes for project chemicals (for both FTE and FFS projects).
14. Ensure safe operations of the biology labs by strict adherence to PIHS safety guidelines and SOPS towards a zero-tolerance policy.

c) Financial

• Adhere to budget (CAPEX/REVEX) as required by the project.

d) Team development & People:

• Interact with all stakeholders to enable timely and accurate communication on project progress towards meeting project goals and timelines.

e) Risk

• Tracking Projects Progress for timely delivery

Profile Requirements

Educational Qualification

• MSc /M. Pharm (Pharmacology) or PhD + post-doctoral in Life sciences/Biochemistry/Biotechnology/ Immunology from a reputed organisation.

Previous Experience

• MSc /M. Pharm (Pharmacology) with 9+ years of experience in the pharma industry or PhD + Post doctoral with 2-5 years in the pharma industry (preferably a CRO).

Industry to be hired from

• Pharma industry (CRO)

Functional Competencies

Innovative thinking, meticulous in documentation, punctual in project documentation and communication to clients, passion for learning and implementation of digitalization and automation techniques.