Analytical / Conjugation - Assistant Manager

2 weeks ago

Mohali, India Panacea Biotec Full time

Roles and Responsibility: Analytical /Conjugation Analytical Characterization - Development of assays for Protein and Carbohydrate characterization. - Standardization and optimization of various Biochemical assays. - Immunochemical methods of analyses such as ELISA, SDS-PAGE, slot blotting and Western blotting. - Instrumental methods of analyses such as LC-MS, Protein sequencing, HPLC, ELISA reader, AKTA, Spectrophotometer and RT-PCR. - Knowledge and implementation of different need based chromatographic techniques in lab. - Analytical method development for physicochemical characterization of Protein and Polysaccharide based vaccines. Conjugation/DSP Process Development - Execute chemical conjugation experiments for polysaccharide-protein and other vaccine platforms. - Support optimization of reaction parameters (e.g., molar ratios, pH, buffers, coupling agents). - Perform quenching, purification, and yield improvement studies. - Operate and optimize purification techniques (UF/DF, chromatography, precipitation, filtration). - Support scale-up studies from bench to pilot level. - Ensure consistency in product yield, recovery, and purity. Documentation & Compliance - Maintain detailed experiment records, data integrity, and lab notebooks. - Support in preparation of technical reports, SOPs, and batch manufacturing records. - Ensure compliance of internal quality standards. Cross-functional Collaboration - Work closely with upstream, formulation, analytical, and quality teams for seamless project execution.

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